one of my favourites :

homers passed out on his pile of stolen sugar in the back yuard and in his sleep he says : "in america... first you get the sugar ... then you get the money ... then you get the women"

lol

"I would kill everyone in this room for a drop of sweet beer" - Homer

hmmmmmm......beer

"me fail english? that's unpossible!" - ralphie

homer hitting a statue of a deer in a park with his car:

Homer: Doh!
Marge: A Deer.
Lisa: A female deer.

"DOPE!!" > all. Or that scream of his, I luagh everytime I hear it!

Ralphie - "My cats breath smells like cat food..."

Scully: Homer, we're going to ask you a few simple yes or no questions. Do you understand?
Homer: Yes. (lie dectector blows up)

that fat dungeon master, treckie, geeky slobby guy finds out some shocking news on the internet and says : "There is no emoticon to express the anger that im feeling! "

Homer: "Merge when I get old promise me you will put me in a home. It's like being a baby but your old enough to appreciate it!"

and

Homer:"Wait a minute Barney, you have to be sober to fly! I mean, it's not like driving."